Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.

@article{Wawrzynczak1992MolecularAB,
  title={Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.},
  author={E. Wawrzynczak and U. Zangemeister‐Wittke and R. Waibel and R. Henry and G. Parnell and A. Cumber and M. Jones and R. Stahel},
  journal={British Journal of Cancer},
  year={1992},
  volume={66},
  pages={361 - 366}
}
An immunotoxin (IT) comprising abrin A chain attached to the mouse monoclonal antibody SWA11, recognising a cell surface antigen highly associated with human small cell lung cancer (SCLC), was synthesised using a hindered disulphide crosslinker, N-succinimidyl 3-(2-pyridyldithio) butyrate (SPDB), and purified by Blue Sepharose CL-6B affinity chromatography. The IT preparation contained monomeric conjugate, composed of one abrin A chain molecule linked to one SWA11 molecule, and was free from… Expand
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