Molecular and biochemical pharmacology of the histamine H4 receptor

@article{Leurs2009MolecularAB,
  title={Molecular and biochemical pharmacology of the histamine H4 receptor},
  author={Rob Leurs and Paul L. Chazot and Fiona C Shenton and Herman D. Lim and Iwan J P de Esch},
  journal={British Journal of Pharmacology},
  year={2009},
  volume={157}
}
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor. 
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Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when dinner is served or orchestrating the elements of inflammation after a mosquito bite, histamine has beenExpand
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