Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster.

@article{Warren2002MolecularAB,
  title={Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster.},
  author={James T. Warren and Anna Petryk and Guillermo Marqu{\'e}s and Michael P Jarcho and Jean-Philippe Parvy and Chantal Dauphin-Villemant and Michael B O'connor and Lawrence I. Gilbert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 17},
  pages={11043-8}
}
Five different enzymatic activities, catalyzed by both microsomal and mitochondrial cytochrome P450 monooxygenases (CYPs), are strongly implicated in the biosynthesis of ecdysone (E) from cholesterol. However, none of these enzymes have been characterized completely. The present data show that the wild-type genes of two members of the Halloween family of embryonic lethals, disembodied (dib) and shadow (sad), code for mitochondrial cytochromes P450 that mediate the last two hydroxylation… CONTINUE READING

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