Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein.

@article{Cortright1995MolecularAB,
  title={Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein.},
  author={Daniel N Cortright and Alessandra Nicoletti and Audrey F. Seasholtz},
  journal={Molecular and cellular endocrinology},
  year={1995},
  volume={111 2},
  pages={147-57}
}
A 37 kDa corticotropin-releasing hormone-binding protein (CRH-BP), distinct from the CRH receptor, is expressed in rat anterior pituitary corticotrophs and many regions of the brain, suggesting that CRH-BP may modulate the biological activity of CRH. In these studies a mouse brain CRH-BP (mCRH-BP) cDNA has been isolated and characterized. The 1666 nucleotide mCRH-BP cDNA is expressed in brain and pituitary and encodes a 322 amino acid protein that is highly homologous to human and rat CRH-BPs… CONTINUE READING
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