Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.

@article{Howe2002MolecularAB,
  title={Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.},
  author={Douglas G Howe and Jesse C. Wiley and G Stanley McKnight},
  journal={Molecular and cellular neurosciences},
  year={2002},
  volume={20 3},
  pages={515-24}
}
The cAMP-dependent protein kinase (PKA) Cbeta gene encodes three isoforms, two of which (Cbeta2 and Cbeta3) are transcribed from neural-specific promoters. Here we report the effects of knocking out all PKA Cbeta subunit isoforms in mice. Total PKA activity was unaffected in the hippocampus and amygdala, while basal PKA activity was reduced by 26% in the brains of Cbetaall(-/-) mice despite a compensatory increase in Calpha protein. Cued fear conditioning was disrupted in Cbetaall(-/-) mice… CONTINUE READING

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