Molecular and Structural Characterization of Polydisperse Polymers and Copolymers by Combining MALDI-TOF Mass Spectrometry with GPC Fractionation

  title={Molecular and Structural Characterization of Polydisperse Polymers and Copolymers by Combining MALDI-TOF Mass Spectrometry with GPC Fractionation},
  author={Giorgio Montaudo and Domenico Garozzo and Maurizio S. Montaudo and Concetto Puglisi and Filippo Samperi},
Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) allows detection of large molecules such as those present in synthetic and natural macromolecules. Until recently, it was reported that MALDI-TOF measurements can provide correct molecular weight (MW) averages only for samples with a narrow MW distribution (M w /M n ≤ 1.20). We have now developed a methodology for polydisperse samples. We recorded the GPC trace of two polydisperse polymeric samples… 
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