Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target

@inproceedings{Vudriko2014MolecularAK,
  title={Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target},
  author={Patrick Vudriko and Tatsunori Masatani and Shinuo Cao and Mohamad Alla Terkawi and Ketsarin Kamyingkird and A. A. Mousa and Paul Franck Adjou Moumouni and Yoshifumi Nishikawa and Xuenan Xuan},
  booktitle={Drug target insights},
  year={2014}
}
Babesia microti is an emerging zoonotic protozoan organism that causes "malaria-like" symptoms that can be fatal in immunocompromised people. Owing to lack of specific therapeutic regiment against the disease, we cloned and characterized B. microti lactate dehydrogenase (BmLDH) as a potential molecular drug receptor. The in vitro kinetic properties of BmLDH enzyme was evaluated using nicotinamide adenine dinucleotide (NAD(+)) as a co-factor and lactate as a substrate. Inhibitory assay was also… CONTINUE READING
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