Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

@article{Tamai1998MolecularAF,
  title={Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*},
  author={I. Tamai and R. Ohashi and J. Nezu and H. Yabuuchi and A. Oku and M. Shimane and Y. Sai and A. Tsuji},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={20378 - 20382}
}
Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine transporters, causes critical symptoms. However, the transporter has not been molecularly identified. In this study, we screened a human kidney cDNA library and assembled a cDNA-encoding OCTN2 as a homologue of the organic cation transporter OCTN1, and then we examined the function of OCTN2 as a carnitine transporter. OCTN2-cDNA encodes a polypeptide of 557 amino acids with 75.8% similarity to OCTN1… Expand
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