Molecular and Cellular Pathobiology p 53 Negatively Regulates the Hepatoma Growth Factor HDGF

Hepatoma-derived growth factor (HDGF) is a secreted heparin-binding growth factor that has been implicated in cancer development and progression. Here, we report that HDGF is a critical target for transcriptional repression by the tumor suppressor p53. Endogenous HDGF expression was decreased in cancer cells with introduction of wild-type p53, which also… CONTINUE READING