Molecular and Cellular Pathobiology Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 toEnhanceGlioblastomaTumorigenicity

Abstract

The EGF receptor (EGFR) is amplified and mutated in glioblastoma, in which its common mutation (DEGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect. This range of activities suggested to us that DEGFR might exert its influence through pleiotropic effectors, and we… (More)

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Cite this paper

@inproceedings{Gomez2014MolecularAC, title={Molecular and Cellular Pathobiology Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 toEnhanceGlioblastomaTumorigenicity}, author={G. Gomez and Stefano Volinia and Carlo M. Croce and Ciro Zanca and Ming Li and Ryan Emnett and David H. Gutmann and Cameron W. Brennan and Frank B. Furnari and Webster K Cavenee}, year={2014} }