Molecular and Cellular Pathobiology Perturbation of Rb , p 53 , and Brca 1 or Brca 2 Cooperate in Inducing Metastatic Serous Epithelial Ovarian Cancer

@inproceedings{Szabova2012MolecularAC,
  title={Molecular and Cellular Pathobiology Perturbation of Rb , p 53 , and Brca 1 or Brca 2 Cooperate in Inducing Metastatic Serous Epithelial Ovarian Cancer},
  author={Ludmila Szabova and Chaoying Yin and Sujata Bupp and Theresa M. Guerin and Jerome J. Schlomer and Deborah B. Householder and Maureen L. Baran and Ming Yi and Yurong Song and Wenping Sun and Jonathan E. McDunn and Philip L. Martin and Terry A. van Dyke and Simone Di and lippantonio},
  year={2012}
}
The majority of human high-grade serous epithelial ovarian cancer (SEOC) is characterized by frequent mutations in p53 and alterations in the RB and FOXM1pathways. A subset of humanSEOCharbors a combination of germline and somatic mutations as well as epigenetic dysfunction for BRCA1/2. Using Cre-conditional alleles and intrabursal induction by Cre… CONTINUE READING