Molecular and Cellular Pathobiology Midkine Promotes Neuroblastoma through Notch 2 Signaling

@inproceedings{Kishida2013MolecularAC,
  title={Molecular and Cellular Pathobiology Midkine Promotes Neuroblastoma through Notch 2 Signaling},
  author={Satoshi Kishida and Ping Mu and Shin Miyakawa and Masatoshi Fujiwara and Tomoyuki Abe and Kazuma Sakamoto and Akira Onishi and Yoshikazu Nakamura and Kenji Kadomatsu},
  year={2013}
}
Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in whichMYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic ganglia. Genetic ablation of midkine in this model delayed tumor formation and reduced tumor incidence… CONTINUE READING
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