Molecular and Cellular Pathobiology Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC 2

@inproceedings{LopezRivera2014MolecularAC,
  title={Molecular and Cellular Pathobiology Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC 2},
  author={Esther Lopez-Rivera and Padmini Jayaraman and Falguni Parikh and Michael A. Davies and Suhendan Ekmekcioglu and Sudeh Izadmehr and Russell Milton and Jerry Edward Chipuk and Elizabeth Ann Grimm and Yeriel D Estrada and Julio A. Aguirre-Ghiso and Andrew G. Sikora},
  year={2014}
}
Melanoma is one of the cancers of fastest-rising incidence in theworld. Inducible nitric oxide synthase (iNOS) is overexpressed in melanoma and other cancers, and previous data suggest that iNOS and nitric oxide (NO) drive survival andproliferation of humanmelanoma cells. However, specificmechanisms throughwhich this occurs are poorly defined. One candidate is the PI3K–AKT–mTOR pathway, which plays a major role in proliferation, angiogenesis, and metastasis of melanoma and other cancers. We… CONTINUE READING