Molecular and Cellular Pathobiology Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

@inproceedings{Soroceanu2013MolecularAC,
  title={Molecular and Cellular Pathobiology Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target},
  author={Liliana Soroceanu and Ryuichi Murase and Chandani Limbad and Eric J. Singer and Juanita Allison and Isabel Adrados and Rumi Kawamura and Arash Pakdel and Yayoi Fukuyo and Daniel Y. Nguyen and Sabeena Jalal Khan and Robert Arauz and Garret L. Yount and D Helen Moore and Pierre-Yves Desprez and Sean D. McAllister},
  year={2013}
}
Glioblastoma is the most common form of primary adult brain tumors. A majority of glioblastomas grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control glioblastoma invasiveness and target them therapeutically. We show here that the transcriptional regulator Id-1 plays a critical role in modulating the invasiveness of glioblastoma cell lines and primary glioblastoma cells. Id-1… CONTINUE READING