Molecular and Cellular Pathobiology Functional InteractionbetweenResponses toLacticAcidosis and Hypoxia Regulates Genomic Transcriptional Outputs

Abstract

Within solid tumor microenvironments, lactic acidosis, and hypoxia each have powerful effects on cancer pathophysiology. However, the influence that these processes exert on each other is unknown. Here, we report that a significant portion of the transcriptional response to hypoxia elicited in cancer cells is abolished by simultaneous exposure to lactic… (More)

Topics

5 Figures and Tables