Molecular and Cellular Pathobiology Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression

Abstract

c-Myc is an oncogene transcription factor that causes cancer in many settings, including solid tumors that arise in the context of organized tissue structures. Given that disruption of tissue architecture frequently occurs in cancer, there is considerable interest in how cell organization impacts oncogene function. A previous report found that organization… (More)

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