Molecular and Cellular Pathobiology Epigenetic Regulator Smchd 1 Functions as a Tumor Suppressor

@inproceedings{Leong2013MolecularAC,
  title={Molecular and Cellular Pathobiology Epigenetic Regulator Smchd 1 Functions as a Tumor Suppressor},
  author={Huei San Leong and Kelan Chen and Yifang Hu and Stanley C. W. Lee and Jason E. Corbin and Miha Pakusch and James M. Murphy and Ian J. Majewski and Gordon K Smyth and Warren S. Alexander and Douglas J. Hilton and Marnie E. Blewitt},
  year={2013}
}
SMCHD1 is an epigenetic modifier of gene expression that is critical to maintain X chromosome inactivation. Here, we show in mouse that genetic inactivation of Smchd1 accelerates tumorigenesis in male mice. Loss of Smchd1 in transformed mouse embryonic fibroblasts increased tumor growth upon transplantation into immunodeficient nude mice. In addition, loss… CONTINUE READING