Molecular and Cellular Pathobiology CLPTM 1 L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells

Genome-wide association studies (GWAS) of 10 different cancers have identified pleiotropic cancer predisposition loci across a region of chromosome 5p15.33 that includes the TERT and CLPTM1L genes. Of these, susceptibility alleles for pancreatic cancer havemapped to theCLPTM1L gene, thus prompting an investigation of the function of CLPTM1L in the pancreas… (More)