Molecular and Cellular Pathobiology Autophagy Enhanced by Microtubule- and Mitochondrion- Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis


Dysfunctional autophagy is associated with tumorigenesis; however, the relationship between the two processes remains unclear. In the present study, we showed that MAP1S levels immediately become elevated in response to diethylnitrosamine-induced or genome instability-driven metabolic stress in a murine model of hepatocarcinoma. Upregulation of MAP1S… (More)