Molecular anatomy of the hair cell's ribbon synapse.

  title={Molecular anatomy of the hair cell's ribbon synapse.},
  author={Revathy C. Uthaiah and A. J. Hudspeth},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 37},
Hearing depends on reliable and temporally precise neurotransmission by cochlear hair cells. The wide dynamic range and high sensitivity with which these cells encode acoustic stimuli are associated with a presynaptic specialization termed the presynaptic dense body or synaptic ribbon. Apposed to the presynaptic density, this spherical or flattened structure tethers a layer of synaptic vesicles and is thought to facilitate their exocytotic fusion. Although defining the molecular constituents of… CONTINUE READING


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