Molecular analysis of yellow fever virus 17DD vaccine strain.

  title={Molecular analysis of yellow fever virus 17DD vaccine strain.},
  author={Palmyra Post and Claudia Nunes Dos Santos and Roasany Piccolotto Carvalho and Oscar de Souza Lopes and Ricardo Galler},
  journal={Memorias do Instituto Oswaldo Cruz},
  volume={86 2},
The Oswaldo Cruz Foundation produces most of the yellow fever (YF) vaccine prepared worldwide. As part of a broader approach to determine the genetic variability in YF 17D seeds and vaccines and its relevance to viral attenuation the 17DD virus was purified directly from chick embryo homogenates which is the source of virus used for vaccination of millions of people in Brazil and other countries for half a century. Neutralization and hemagglutination tests showed that the purified virus is… CONTINUE READING