Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.

@article{Zee1994MolecularAO,
  title={Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.},
  author={Ate G J Van Der Zee and E G E Liesbeth de Vries and Harry Hollema and Stanley B. Kaye and Robert Brown and W. Nicol Keith},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1994},
  volume={5 1},
  pages={75-81}
}
BACKGROUND DNA topoisomerase II enzymes are key targets for the group of anti-tumour agents known as topoisomerase inhibitors. In general, cell lines which express high levels of topoisomerase II are sensitive to the cytotoxic effects of the topoisomerase poisons. The levels of topoisomerase II expression in tumour biopsies may therefore predict response to treatment with enzyme inhibitors. In the current study we have analysed ovarian tumours for expression of topoisomerase II alpha and… CONTINUE READING