Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms

@article{Reddy1984MolecularAO,
  title={Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms},
  author={P. Reddy and W. Zehring and D. Wheeler and V. Pirrotta and M. Rosbash},
  journal={Cell},
  year={1984},
  volume={38},
  pages={701-710}
}
Key MethodWe have isolated and analyzed DNA sequences encompassing the period (per) locus of Drosophila melanogaster. The location of this clock gene was delimited by the molecular mapping of chromosome aberrations at or very near the per locus. At least five RNAs are transcribed from this region. One of these transcripts, a 0.9 kb species, is strongly implicated in per's control of biological rhythms. Two independently isolated arrhythmic mutations at the per locus dramatically reduce the level of this…Expand
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