Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.

@article{Chiossone2007MolecularAO,
  title={Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.},
  author={Laura Chiossone and Chiara Vitale and Francesca Cottalasso and Sara Moretti and Bruno Azzarone and Alessandro Moretta and Maria Cristina Mingari},
  journal={Blood},
  year={2007},
  volume={109 9},
  pages={3767-75}
}
Steroids have been shown to inhibit the function of fresh or IL-2-activated natural killer (NK) cells. Since IL-15 plays a key role in NK-cell development and function, we comparatively analyzed the effects of methylprednisolone on IL-2- or IL-15-cultured NK cells. Methylprednisolone inhibited the surface expression of the major activating receptors NKp30 and NKp44 in both conditions, whereas NK-cell proliferation and survival were sharply impaired only in IL-2-cultured NK cells. Accordingly… CONTINUE READING

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