Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.

@article{Spigaglia2009MolecularAO,
  title={Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.},
  author={Patrizia Spigaglia and Fabrizio Barbanti and Thomas J. Louie and Fr{\'e}d{\'e}ric Barbut and Paola Mastrantonio},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 6},
  pages={2463-8}
}
Recent studies have suggested that exposure to fluoroquinolones represents a risk factor for the development of Clostridium difficile infections and that the acquisition of resistance to the newer fluoroquinolones is the major reason facilitating wide dissemination. In particular, moxifloxacin (MX) and levofloxacin (LE) have been recently associated with outbreaks caused by the C. difficile toxinotype III/PCR ribotype 027/pulsed-field gel electrophoresis type NAP1 strain. In this study, we… CONTINUE READING

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