Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

@article{Lin2001MolecularAO,
  title={Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.},
  author={Hsi-Hsien Lin and Martin Stacey and Claire Saxby and Vroni Knott and Yasmin Chaudhry and Daniel F Evans and Siamon Gordon and Andrew J. McKnight and Penny A Handford and Susan Lea},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={24160-9}
}
Epidermal growth factor-like (EGF) and short consensus repeat (SCR) domains are commonly found in cell surface and soluble proteins that mediate specific protein-protein recognition events. Unlike the immunoglobulin (Ig) superfamily, very little is known about the general properties of intermolecular interactions encoded by these common modules, and in particular, how specificity of binding is achieved. We have dissected the binding of CD97 (a member of the EGF-TM7 family) to the complement… CONTINUE READING

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