Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

  title={Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.},
  author={Norihiko Kawamata and Roberta Morosetti and Carl W. Miller and D Park and Konstantin S. Spirin and Tsuyoshi Nakamaki and Seisho Takeuchi and Yuki Hatta and Jennifer Simpson and S Wilcyznski},
  journal={Cancer research},
  volume={55 11},
Cyclin and cyclin-dependent kinase (CDK) complexes play important roles in controlling the cell cycle. The CDK inhibitors (CDKIs) inhibit the kinase activities of the complexes and block transitions of the cell cycle. Recently several CDKI genes have been cloned, and evidence suggests that at least a couple of these may be tumor suppressor genes. In this study, the partial structure of a CDKI gene, p27/Kip1, was determined. In addition, a large number of human cancers (432 cases) and cancer… CONTINUE READING


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