Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes

@inproceedings{Ploutarchou2015MolecularAO,
  title={Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes},
  author={Panayiota Ploutarchou and Pedro Nel Florez Melo and Anthony J Day and Caroline M. Milner and Suzannah A Williams},
  booktitle={Reproduction},
  year={2015}
}
During follicle development, oocytes secrete factors that influence the development of granulosa and cumulus cells (CCs). In response to oocyte and somatic cell signals, CCs produce extracellular matrix (ECM) molecules resulting in cumulus expansion, which is essential for ovulation, fertilisation, and is predictive of oocyte quality. The cumulus ECM is largely made up of hyaluronan (HA), TNF-stimulated gene-6 (TSG-6, also known as TNFAIP6), pentraxin-3 (PTX3), and the heavy chains (HCs) of… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep

R Varnosfaderani Sh, S Ostadhosseini, +5 authors MH Nasr-Esfahani
  • Theriogenology
  • 2013
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…