Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.

@article{SnchezCspedes2000MolecularAO,
  title={Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.},
  author={Montserrat S{\'a}nchez-C{\'e}spedes and Kenji Okami and Paul M. Cairns and David Sidransky},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={27 3},
  pages={319-22}
}
The candidate tumor-suppressor gene ING1 encodes p33(ING1), a nuclear protein which physically interacts with TP53. It has been shown that p33(ING1) acts in the same biochemical pathway as TP53, leading to cell growth inhibition. Interestingly, a rearrangement of the ING1 gene was found in a neuroblastoma cell line, supporting its involvement in tumor development. Because ING1 resides on the long arm of chromosome 13 (13q34) (a region frequently deleted in many tumor types), we sought to… CONTINUE READING

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