• Biology, Medicine
  • Published in Development 1990

Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila.

@article{Gridley1990MolecularAO,
  title={Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila.},
  author={Thomas Gridley and Douglas A. Gray and Terry L Orr-Weaver and Philippe Soriano and David E Barton and Uta Francke and Rudolf Jaenisch},
  journal={Development},
  year={1990},
  volume={109 1},
  pages={
          235-42
        }
}
The Mov 34 mutation is a recessive embryonic lethal mutation caused by retroviral integration in the murine germline. This integration disrupts a transcription unit that appears to encode a novel protein. The Mov 34 proviral integration is located on mouse chromosome 8 and the human homolog of this gene has been mapped to chromosome region 16q23-q24. An evolutionarily conserved syntenic relationship exists between this region of human chromosome 16 and a region of mouse chromosome 8 that also… CONTINUE READING

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Improved tools for biological sequence comparison.

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