Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes

Abstract

The vast majority of tumors of the pancreas are ductal adenocarcinomas. This cancer type has an extremely poor prognosis and in many Western countries, it represents the fifth leading cause of cancer-related death. Pancreatic ductal adenocarcinomas exhibit the highest incidence of activating KRAS (Ki-Ras) mutations observed in any human cancer. It was… (More)
DOI: 10.1007/s00428-006-0191-8

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@article{Immervoll2006MolecularAO, title={Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes}, author={Heike Immervoll and Dag Hoem and Kalaiarasy Kugarajh and Solrun J. Steine and Anders Molven}, journal={Virchows Archiv}, year={2006}, volume={448}, pages={788-796} }