Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients.

@article{Nathan2002MolecularAO,
  title={Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients.},
  author={Cherie-Ann O Nathan and Nazanin Amirghahri and Cliff Rice and Fleurette W. Abreo and Runhua Shi and Frederick J Stucker},
  journal={The Laryngoscope},
  year={2002},
  volume={112 12},
  pages={2129-40}
}
OBJECTIVES/HYPOTHESIS Molecular analysis of surgical margins is playing an increasingly important role in establishing surgical margins. Most markers lack the sensitivity and ease of applicability for effective clinical use. To date, the proto-oncogene eIF4E (4E) is elevated in 100% of head and neck squamous cell carcinoma tumors and is of prognostic value in predicting recurrence. In a retrospective study, 4E overexpression in the margins appeared to be a more sensitive predictor of recurrence… CONTINUE READING
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