Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men.

@article{Harris2006MolecularAO,
  title={Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men.},
  author={Talbot Page Joel Balbien Stephanie Harris and Katherine P. Gomas and Fred Weir and Andrew J. Holyoake and Pete Mchugh and Min-hui Wu and Y Sin and Iris L Sin and Frank Y. T. Sin},
  journal={International journal of andrology},
  year={2006},
  volume={29 3},
  pages={421-33}
}
CAG trinucleotide repeat length in the nuclear polymerase gamma gene (POLgamma) has been shown to be associated with men with reduced fertility. The present study investigated the frequency of CAG repeat length genotypes and three exonuclease motifs of the POLgamma in relation to the frequency of mitochondrial nucleotide substitutions. DNA from semen samples of 93 normozoospermic men and 192 non-normozoospermic men was isolated and the specific regions of the genes were amplified by polymerase… CONTINUE READING