Molecular analysis of oral lichen planus. A premalignant lesion?

  title={Molecular analysis of oral lichen planus. A premalignant lesion?},
  author={Lewei Zhang and Claus Michelsen and Xing Cheng and Tao Zeng and Robert W. Priddy and Miriam Pearl Rosin},
  journal={The American journal of pathology},
  volume={151 2},
Oral lichen planus (OLP) is a common mucosal condition that is considered premalignant by some, although others argue that only lichenoid lesions with dysplasia are precancerous. To address the question of whether OLP without dysplasia is premalignant, we used microsatellite analysis to examine 33 cases of OLP for allelic loss at nine loci located on chromosomes 3p, 9p, and 17p. Loss of heterozygosity (LOH) on these three arms occurs frequently in oral tumors, and the presence of these… CONTINUE READING
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