Molecular analysis of mammalian circadian rhythms.

  title={Molecular analysis of mammalian circadian rhythms.},
  author={Steven M. Reppert and David R Weaver},
  journal={Annual review of physiology},
In mammals, a master circadian "clock" resides in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. The SCN clock is composed of multiple, single-cell circadian oscillators, which, when synchronized, generate coordinated circadian outputs that regulate overt rhythms. Eight clock genes have been cloned that are involved in interacting transcriptional-/translational-feedback loops that compose the molecular clockwork. The daily light-dark cycle ultimately impinges on the control of… CONTINUE READING
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