Molecular analysis of iron overload in beta2-microglobulin-deficient mice.

  title={Molecular analysis of iron overload in beta2-microglobulin-deficient mice.},
  author={Martina U. Muckenthaler and Pedro Henrique de Carli Rodrigues and Maria G Macedo and Bel{\'e}n Mi{\~n}ana and Karen Brennan and Elsa Maria Cardoso and Matthias W. Hentze and Maria Leonor Baptista de Sousa},
  journal={Blood cells, molecules & diseases},
  volume={33 2},
Beta2-microglobulin knockout (beta2m-/-) mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis. The mechanism of iron accumulation in this mouse model may be more complex than involving the MHC class I-like protein HFE. We report that beta2m-deficient mice, like Hfe-/- mice, lack the adaptive hepatic hepcidin mRNA increase to iron overload. The inverse correlation of hepatic iron levels and hepcidin mRNA expression in six beta2m-/- mice underlines… CONTINUE READING


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