Molecular analysis of germline t(3;6) and t(3;12) associated with conventional renal cell carcinomas indicates their rate-limiting role and supports the three-hit model of carcinogenesis.

@article{Yusenko2010MolecularAO,
  title={Molecular analysis of germline t(3;6) and t(3;12) associated with conventional renal cell carcinomas indicates their rate-limiting role and supports the three-hit model of carcinogenesis.},
  author={M. Yusenko and A. Nagy and G. Kovacs},
  journal={Cancer genetics and cytogenetics},
  year={2010},
  volume={201 1},
  pages={
          15-23
        }
}
  • M. Yusenko, A. Nagy, G. Kovacs
  • Published 2010
  • Biology, Medicine
  • Cancer genetics and cytogenetics
  • We describe the molecular analysis of chromosomal rearrangements in familial t(3;6)(p12.3;q24.3) and t(3;12)(q13.13;q24.23) associated with the development of conventional renal cell carcinomas (RCC). We mapped the breakpoints by high-density oligo array comparative genomic hybridization of tumor cells in t(3;6) at chromosome 3p12.3 between PDZRN3 and CNTN3; the chromosomal rearrangement at 6q24.3 was mapped within the seventh intron of the STXBP5 gene. In the second case, the break at 3q13.13… CONTINUE READING
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