Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

@article{Cristescu2015MolecularAO,
  title={Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes},
  author={Razvan Cristescu and Jeeyun Lee and Michael V Nebozhyn and Kyoung-Mee Kim and Jason C. Ting and Swee Seong Wong and Jiangang Liu and Yong Gang Yue and Jian Wang and Kun Yu and Xiang S. Ye and In-Gu Do and Shawn Liu and Lara Gong and Jake Fu and Jason Gang Jin and Min Gew Choi and Tae Sung Sohn and Jun Hee Lee and Jae Moon Bae and Seung Tae Kim and Se Hoon Park and Insuk Sohn and Sin-Ho Jung and Patrick B. O. Tan and Ronghua Chen and James Hardwick and Won Ki Kang and Mark L. Ayers and Dai Hongyue and Christoph Reinhard and Andrey Loboda and Sung Kim and Amit Aggarwal},
  journal={Nature Medicine},
  year={2015},
  volume={21},
  pages={449-456}
}
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would encompass this heterogeneity and provide useful clinical information. We use gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis. The mesenchymal-like type includes diffuse-subtype tumors with the worst prognosis, the tendency to occur at an earlier… CONTINUE READING

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