Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal.

@article{Jennings2007MolecularAO,
  title={Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal.},
  author={Cameron V. Jennings and Ambroise Dioum Ahouidi and M. Zilversmit and Amy Kristine Bei and Julian C. Rayner and Ousmane Fall Sarr and Omar Ndir and Dyann F Wirth and Souleymane Mboup and Manoj Duraisingh},
  journal={Infection and immunity},
  year={2007},
  volume={75 7},
  pages={3531-8}
}
The human malaria parasite, Plasmodium falciparum, utilizes multiple ligand-receptor interactions for the invasion of human erythrocytes. Members of the reticulocyte binding protein homolog (PfRh) family have been shown to be critical for directing parasites to alternative erythrocyte receptors that define invasion pathways. Recent studies have identified gene amplification, sequence polymorphism, and variant expression of PfRh paralogs as mechanisms underlying discrimination between pathways… CONTINUE READING
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