Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.

  title={Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.},
  author={Ryuma Haraguchi and Jun Motoyama and Hiroshi Sasaki and Yoshihiko Satoh and Shinichi Miyagawa and Naomi Nakagata and Anne M. Moon and Gen Yamada},
  volume={134 3},
The urogenital and reproductive organs, including the external genitalia, bladder and urethra, develop as anatomically aligned organs. Descriptive and experimental embryology suggest that the cloaca, and its derivative, the urogenital sinus, contribute to the formation of these organs. However, it is unknown how the primary tissue lineages in, and adjacent to, the cloaca give rise to the above organs, nor is bladder formation understood. While it is known that sonic hedgehog (Shh) is expressed… CONTINUE READING


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