Molecular analysis of commensal host-microbial relationships in the intestine.

@article{Hooper2001MolecularAO,
  title={Molecular analysis of commensal host-microbial relationships in the intestine.},
  author={Lora V. Hooper and Melissa H. Wong and Angelika Thelin and Lennart Hansson and Per G. Falk and Jeffrey I. Gordon},
  journal={Science},
  year={2001},
  volume={291 5505},
  pages={
          881-4
        }
}
Human beings contain complex societies of indigenous microbes, yet little is known about how resident bacteria shape our physiology. We colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the normal mouse and human intestinal microflora. Global intestinal transcriptional responses to colonization were observed with DNA microarrays, and the cellular origins of selected responses were established by laser-capture microdissection. The results reveal that this… 

How host-microbial interactions shape the nutrient environment of the mammalian intestine.

Humans and other mammals are colonized by a vast, complex, and dynamic consortium of microorganisms. One evolutionary driving force for maintaining this metabolically active microbial society is to

Diversity of the Human Intestinal Microbial Flora

A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.

Honor thy symbionts

  • Jian XuJ. Gordon
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
Interdisciplinary studies of the effects of the intestinal environment on genome structure and function should provide important new insights about how microbes and humans have coevolved mutually beneficial relationships and new perspectives about the foundations of the authors' health.

Bacteroides thetaiotaomicron in the gut: molecular aspects of their interaction.

Enteric Flora in Health and Disease

It is important to underscore that the specialised lymphoid follicles of the gut mucosa are the major sites for induction and regulation of the immune system.

The Yin and Yang of host-commensal mutualism

It is reported that chronic intestinal inflammation induces commensal E. coli to upregulate stress response genes that paradoxically limit their growth in vivo and the findings are discussed in the context of host-microbial interactions in health and disease and a developing paradigm that may distinguish pathogens from commensals.

Commensal Host-Bacterial Relationships in the Gut

The current genomic revolution offers an unprecedented opportunity to identify the molecular foundations of symbionts and commensals so that the authors can understand how they contribute to their normal physiology and how they can be exploited to develop new therapeutic strategies.

Intestinal microbiota and its functions

...

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