Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution.

  title={Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution.},
  author={Brooke E. Sylvester and Dezheng Huo and Andrey Ilyich Khramtsov and Jing Zhang and Rana V Smalling and Sope Olugbile and Blase N Polite and Olufunmilayo I. Olopade},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 2},
PURPOSE African American colorectal cancer patients have worse survival outcomes than Caucasian patients. To determine whether differences exist in the molecular mechanisms driving colorectal cancer between African Americans and Caucasians, we characterized patient tumors from a single institution by assessing genetic alterations involved in colorectal cancer progression and response to treatment. EXPERIMENTAL DESIGN We retrospectively examined 448 African Americans and Caucasians diagnosed… CONTINUE READING
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