Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.

@article{Moria2010MolecularAO,
  title={Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.},
  author={Rosa M Mori{\~n}a and Christoph Knorr and Bianca Haase and Tosso Leeb and T Seuberlich and Andres Zurbriggen and Gottfried Brem and Ekkehard Sch{\"u}tz and Bertram Brenig},
  journal={Animal genetics},
  year={2010},
  volume={41 1},
  pages={85-8}
}
Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the CHST8 gene were identified by comparative sequencing and… CONTINUE READING