Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.

@article{WisniewskaKruk2014MolecularAO,
  title={Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.},
  author={Joanna Wisniewska-Kruk and Ingeborg Klaassen and Ilse M. C. Vogels and Aaron Len Magno and C. M. Lai and Cornelis J. F. van Noorden and Reinier Otto Schlingemann and Elizabeth Piroska Rakoczy},
  journal={Experimental eye research},
  year={2014},
  volume={122},
  pages={123-31}
}
The molecular mechanisms of vascular leakage in diabetic macular edema and proliferative retinopathy are poorly understood, mainly due to the lack of reliable in vivo models. The Akimba (Ins2(Akita)VEGF(+/-)) mouse model combines retinal neovascularization with hyperglycemia, and in contrast to other models, displays the majority of signs of advanced clinical diabetic retinopathy (DR). To study the molecular mechanism that underlies the breakdown of the blood-retinal barrier (BRB) in diabetic… CONTINUE READING

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