Molecular analysis of axon repulsion by the notochord.

  title={Molecular analysis of axon repulsion by the notochord.},
  author={Christopher N G Anderson and Kunimasa Ohta and Marie M Quick and Angeleen Fleming and Roger Keynes and David Tannahill},
  volume={130 6},
During development of the amniote peripheral nervous system, the initial trajectory of primary sensory axons is determined largely by the action of axon repellents. We have shown previously that tissues flanking dorsal root ganglia, the notochord lying medially and the dermamyotomes lying laterally, are sources of secreted molecules that prevent axons from entering inappropriate territories. Although there is evidence suggesting that SEMA3A contributes to the repellent activity of the… CONTINUE READING