Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.

@article{Russo1989MolecularAO,
  title={Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.},
  author={Giandomenico Russo and Masaharu Isobe and Richard A. Gatti and Janet Finan and Olcay A. Batuman and Kay F Huebner and Peter C. Nowell and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 2},
  pages={602-6}
}
We have detected and cloned two rearrangements in the T-cell receptor alpha locus from a clone of somatic cell hybrids carrying a t(14;14)(q11;q32) chromosomal translocation derived from an ataxia telangiectasia patient with T-cell chronic lymphocytic leukemia. The T-cell clone carrying the t(14;14) chromosomal translocation was known to be present for… CONTINUE READING