Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.

@article{Watanabe1996MolecularAO,
  title={Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.},
  author={Masahiko Watanabe and B C Zingg and Harvey W. Mohrenweiser},
  journal={American journal of human genetics},
  year={1996},
  volume={58 2},
  pages={308-16}
}
Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have been previously identified in families during the screening of approximately 2,000 newborn children for quantitative variation in activity of 12 erythrocyte enzymes. The frequency of the trait was 9/1,713 individuals in the Caucasian population and 7/168 individuals among the African-American population studied. Genetic transmission of the trait was confirmed in all families. The frequency of the presumptive… CONTINUE READING