Molecular analysis of TCR junctional variability in individual infiltrated islets of non-obese diabetic mice: evidence for the constitution of largely autonomous T cell foci within the same pancreas.

Abstract

Insulitis develops in non-obese diabetic (NOD) mice as a multicentric and asynchronous process. In an effort to understand how this T cell mediated process expands within each islet and propagates between the islets of the same pancreas, we have analyzed the junctional diversity of TCR V beta 6 and V beta 8.2 transcripts cloned from infiltrated islets. The… (More)

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@article{Sarukhn1995MolecularAO, title={Molecular analysis of TCR junctional variability in individual infiltrated islets of non-obese diabetic mice: evidence for the constitution of largely autonomous T cell foci within the same pancreas.}, author={Adelaida Sarukh{\'a}n and Pierre Bedossa and Henri Jean Garchon and J. Bach and Claude Carnaud}, journal={International immunology}, year={1995}, volume={7 1}, pages={139-46} }