Molecular analysis of Sindbis virus pathogenesis in neonatal mice by using virus recombinants constructed in vitro.

@article{Polo1988MolecularAO,
  title={Molecular analysis of Sindbis virus pathogenesis in neonatal mice by using virus recombinants constructed in vitro.},
  author={J. L. Mart{\'i}n Polo and Nancy L. Davis and Charles M. Rice and Henry V. Huang and Robert E. Johnston},
  journal={Journal of virology},
  year={1988},
  volume={62 6},
  pages={
          2124-33
        }
}
Genetic loci affecting Sindbis virus pathogenesis in neonatal mice have been examined by using a full-length cDNA clone of the virus (Toto1101). The full-length cDNA is linked to a bacteriophage SP6 promoter to facilitate the synthesis of infectious RNA transcripts in vitro. Virus derived from Toto1101 showed reduced virulence (attenuation) in neonatal mice. Replacement of the E1 glycoprotein and 6K genes of Toto1101 with cloned E1 and 6K genes derived from a virulent Sindbis virus strain… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model.

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Infectivity variation and genetic diversity among strains of Western equine encephalitis virus.

VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular basis of Sindbis virus neurovirulence in mice.

VIEW 4 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Molecular determinants of alphavirus neuropathogenesis in mice.

VIEW 1 EXCERPT
CITES BACKGROUND

The Pathogenesis of Alphaviruses

VIEW 1 EXCERPT
CITES BACKGROUND