Molecular analysis of Neanderthal DNA from the northern Caucasus

@article{Ovchinnikov2000MolecularAO,
  title={Molecular analysis of Neanderthal DNA from the northern Caucasus},
  author={Igor V. Ovchinnikov and Anders G{\"o}therstr{\"o}m and Galina P. Romanova and Vitaliy M. Kharitonov and Kerstin Lid{\'e}n and William Goodwin},
  journal={Nature},
  year={2000},
  volume={404},
  pages={490-493}
}
The expansion of premodern humans into western and eastern Europe ∼40,000 years before the present led to the eventual replacement of the Neanderthals by modern humans ∼28,000 years ago. Here we report the second mitochondrial DNA (mtDNA) analysis of a Neanderthal, and the first such analysis on clearly dated Neanderthal remains. The specimen is from one of the eastern-most Neanderthal populations, recovered from Mezmaiskaya Cave in the northern Caucasus. Radiocarbon dating estimated the… Expand
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Neanderthals
  • K. Harvati
  • Encyclopedic Dictionary of Archaeology
  • 2021
Neanderthals are a group of fossil humans that inhabited Western Eurasia from approximately 300 to 30,000 years ago (ka). They vanished from the fossil record a few millennia after the first modern… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
DNA sequence of the mitochondrial hypervariable region II from the neandertal type specimen.
TLDR
The results support the concept that the Neandertal mtDNA evolved separately from that of modern humans for a substantial amount of time and lends no support to the idea that they contributed mtDNA to contemporary modern humans. Expand
Neandertal DNA Sequences and the Origin of Modern Humans
TLDR
Neandertals went extinct without contributing mtDNA to modern humans, according to sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, which show that the Neandertal sequence falls outside the variation of modern humans. Expand
Mitochondrial sequences show diverse evolutionary histories of African hominoids.
TLDR
The results are relevant to the origin of zoonotic diseases, including HIV-1, and call into question some aspects of the current taxonomic treatment and conservation management of gorillas and chimpanzees. Expand
Neandertals and modern humans in Western Asia
Issues of Evolution and Chronology: Evolutionary Implications of Altered Perspectives on Hominine Demes and Populations in the Later Pleistocene of Western Eurasia F.C. Howell. Chronological and… Expand
A Plio-Pleistocene hominid from Dmanisi, East Georgia, Caucasus
TLDR
The mandible found at Dmanisi is identified as belonging to the species Homo erectus, of which it is the earliest known representative in western Eurasia and shows a number of similarities to the African and Chinese representatives of this species. Expand
Direct radiocarbon dates for Vindija G(1) and Velika Pecína late Pleistocene hominid remains.
TLDR
New accelerator mass spectrometry radiocarbon dates taken directly on human remains from the Late Pleistocene sites of Vindija and Velika Pecina in the Hrvatsko Zagorje of Croatia raise the question of when early modern humans first dispersed into Europe and have implications for the nature and geographic patterning of biological and cultural interactions between these populations and the Neandertals. Expand
Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.
TLDR
A new mathematical method for estimating the number of transitional and transversional substitutions per site, as well as the total number of nucleotide substitutions, suggested that the transition/transversion ratio for the entire control region was approximately 15 and nearly the same for the two species. Expand
Substitution rate variation among sites in mitochondrial hypervariable region I of humans and chimpanzees.
TLDR
The maximum-likelihood method was used to estimate the gamma shape parameter alpha for variable substitution rates among sites for HVI from humans and chimpanzees to provide estimates for future studies, and an alpha of 0.4 appears suitable for both humans and chimpanzee. Expand
HvrBase: compilation of mtDNA control region sequences from primates
TLDR
HvrBase is a compilation of human and ape mtDNA control region sequences that comprises 5846 human sequences from hypervariable region I (HVRI) and 2302 human sequencesFrom apes, 295 HVRI sequences and 13 HVRII sequences are available. Expand
Constraints on early Earth differentiation from hafnium and neodymium isotopes
INFERENCES about the early evolution of the Earth's crust and mantle have come largely from the study of isotope systematics— in particular, those of neodymium1–5. Neodymium isotope data from the… Expand
...
1
2
3
4
5
...